Microd GLP -1 drugs such as Ozmpic and Wegovy in a height – but do you work? star-news.press/wp

Madison Burgis decided to be serious about weight loss when the scale reached 91 kg (200 pounds). I started taking OzemPic. The medicine did better than I thought it was possible: even at a low start dose, it lost more than 2 kg (5 pounds) during the first week.

However, the problems began when Borges, the 25 -year -old healthcare director from Bloomfield, Michigan, increased, according to the manufacturer’s instructions. “The highest doses were approximately me,” she says. Hit constipation, nausea, diarrhea, acid bounce severely and make eating difficult. This is when she decided to retreat to a lower dose and determine whether she could continue to see the benefits.

Burges is just one of an increasing number of people who “lose a minute”-a practice that is usually associated with a drug like LSD and Psilocybin-by eating less measurements of measurements that lose weight like Wegovy and Mountjaro (see “How do they work?”less).

For some, hope is to avoid side effects during weight loss, while others want to take advantage of the anti -inflammatory effect of these drugs or reap their other benefits to the heart and brain (see “Wonder Medicine”?, less). The mini falls of the drugs were You are promoting to expand the longevity Written by wealthy elites such as technical entrepreneurs, Brian Johnson, and it is rumored to be a secret weapon for Hollywood stars who want to search for photo calls.

The question is, does this experiment work outside the low -dose stickers?

Medicines such as Ozmpic, Mountrao and ILK come in pre -loaded injection pens. In conjunction with the health care provider, users usually follow the dose system rising. Take and woven. In the first month, users take a low preliminary dose of 0.25 milligrams per week. This doubles after that, then doubles again until the “maintenance” dose is achieved from 1.7 or 2.4 mg per week, which is then in the long run. These standard doses are the only strengths studied in clinical trials on a large scale.

For this reason, this losing drug has not been approved by the US Food and Drug Administration (FDA) or by other health authorities. But this did not prevent people from trying it Ziyad Al-Aly In the affairs of the old warriors, the St. Louis Health Care System in Missouri.

For Borges, small doses ranging from 0.25 and 0.5 mg per week have achieved success: I lost 27 kg (60 lbs) and reached its weight without problematic side effects. “At lower doses, I have no symptoms,” she says. Burges continues to take the medicine to avoid weight restoring – an additional motivation for a loss of minute.

ignition

Another exclusive surgery, Katie SorensenA nurse, a nurse who has a medical practice in Golden, Colorado, says low doses of Terzopatid have generally improved the quality of her life. It takes 2 mg per week (the recommended beginner dose is 2.5 mg) and claims that the accurate capacity has reduced its inflammation, as it becomes clear from the presence of less pain and pain, and given more energy, and generally helped it choose a more healthy diet. “There is less ideas about food and the desire for less than that makes it easier to choose healthy foods,” Sorensen says.

Alhaly’s A recent study in nature A set of health benefits in addition to weight loss for those who take medications, including a decrease in the risk of drug use disorders, Alzheimer’s disease, dementia, clotting disorders and many other cases. But these were in higher doses and there are no data to show that similar results will occur in those with Microdose.

“For most people, we need higher doses to see the results of weight loss and diabetes, but there are some exceptions,” says Caroline Francavila, a obesity doctor in Denver, Colorado. The main clinical trials looking for a huge semoliotide have found a significant contrast. around 35 per cent of people “Super respondents”The achievement of weight loss exceeds 20 percent; Its sensitivity to the drug may mean that it takes much less of them to see the results.

longevity

Whether the drug is already a fountain of young people that are still unclear, but we know that they can do so Reducing inflammation. “It is reasonable to provide accurate capacity some (anti-inflammatory) benefits … but we do not know yet.”

However, medications should not be taken randomly. “There should be a medical problem we improve if we will use medications at any dose,” says Francialala. It may be dangerous for some people, especially those who have Pancreatitis that was not resolvedSome types of thyroid cancer and some problems of the digestive system, such as StomachA condition leads to the delay in emptying the stomach.

In the United States, many of those who issue GLP-1 drugs suffer from compound pharmacies. These drugs are specially designed with pharmaceutical ingredients when brand medications are not available. This is a cheaper option than buying Wegovy and other brands in retail pharmacies, but it comes with the risk of pollution and inaccurate doses, because these injections do not depend on them for safety and quality. However, in the coming months, hijacker injections are guaranteed It may become illegal in the United StatesBecause there is no longer a shortage of branded versions. This will have harmful repercussions on precise sensors such as Borges, who have begun to use complex injection instead of OzemPic in an attempt to avoid weight restoring.

However, Burges is not planning to stop Microdormal Smaglutide any time soon. “It is a tool that helped me with a journey to lose weight,” she says.