summary: Deeded genes mutations, which have been believed to have long been affected, may face hidden defects, including more medical problems, shorter educational achievement, and reduce reproductive success. A study of more than 300,000 people reveals that people with recessive genes of mental disability are especially affected, although there is only one genetic version.
These carriers were more likely to develop short school professions, indicating that the stresses of evolutionary selection are still apparently working on these silent genes. The results challenge the assumptions of textbooks and provide new visions on how to choose natural and sexual selection of human genome.
Main facts:
- Hidden effect: Genetics carriers for recessive diseases show more medical diagnoses and low reproductive success.
- Education effect: Mental disability genes vector attends school for less years.
- Sexture: The decrease in reproductive success may result from hidden effects that affect the choice of its companion and social results.
source: Radbod University
As a group, recessive disorders are slightly less healthy and have a reduced chance to get offspring.
This disadvantage is the largest of the dedicated gene tankers for mental disability, and it is reflected in a shorter school profession and the increase in lack of children, according to a research from Radboudumc published in The nature of human behavior.
It’s time to rewrite school books?
Dominant
Researchers from Radboudumc, the Ministry of Human Genetics, showed a great thing in the 2014 publication in nature.
Contrary to expectations, the variables inherited in the genes were rarely responsible for mental disability.
In the vast majority, the disability arose from a spontaneous mutation: a boom that the parents did not have, but suddenly appear in the child. It is a biological fact that about a hundred spontaneous mutations occur in the genetic material for each child. Mutations that do not arise from parents.
On average, only one of these mutations affects the gene. Only a small part of these affects one of the hundreds of genes that can cause an intellectual disability. But rare events are still taking place. Most intellectual disabilities arise in this way.
From dominant to recessive
“There was something else.
“Children get a gene from the father and mother by default. When a single boom in the child leads to an intellectual disability, this is called a mutation in a The dominant gene.
Other mutations affect Recessive genes. The presence of one mutation in a cupping gene, in principle, has no effect on the carrier. A barrier arises only if the mutation is in both copies of the offensive gene.
“On our clinic, we found a very few of these double mutations in the recessive genes in children with mental disabilities. Strange, because there are more genes than the genes dominated this. So we asked: Where did all of these recessive mutations go from?”
More medical diagnoses
The question led to a long and comprehensive inspection, its results were now published The nature of human behavior.
“We have first achieved the number of times when these recessive mutations occur in the population,” says Han Bruner, a professor of clinical genetics, like Gilison, like Gilison, involved in both publications.
To do this, data has been examined by more than 300,000 people listed at the biological bank in the UK.
“We have found that every person carries two mutations in any of the recessive genes 1900. According to textbooks, transport companies should not face these recessive genes any defect.
“However, we found that, as a group, they have more medical diagnoses, and a little lower atomic. Thus, it is unlikely that their genes are transferred to recessive disorders.”
Lower education
Compared to other recessive genes, genes of mental disability were the most absence. Apparently, there is another aspect of playing here. UK biological bank data provides an idea.
Gilsen: “The generous gene carrier for mental disability goes to school for a shorter period, indicating that they have a lower level of education. You are in mind, these tankers, according to the current theory, are not affected at all with their mobile gene.”
You are likely to be without children
Consequently, the independent genes holders of mental disability have reduced reproductive success and a shorter school profession.
Brunner: “In 1859, Darwin was published On the origin of species by natural selection. It is mainly related to survival, about genes that make you strong and healthy, about natural selection.
After twelve years he wrote Man’s descent, choice in relation to sexHe refined his theory. You can have great genes, but if no one wants to have children with you, these genes will not pass.
“The principle of sexual choice. We do not make it clear that it is a solid rock here, but if you have to give a reason to these results – the partially list on a lot of social research – sexual selection is the most obvious interpretation.”
Re -writing textbooks
This research clearly shows that recessive transport companies have a selection defect at the group level. In the past, this has been indicated to the specific disorders. Here, for the first time this appears to recessive disorders in general. He may go to textbooks.
Brunner: “Our research indicates that our genes are still constantly changing, and that the genetic scene is still in the state of movement, and that development continues. The idea that our development in the modern era has stopped stopping health care and other amenities are incorrect.”
Just as it will not be at all, Gilissen suggests: “We will never be improved for the problem of tomorrow.”
On this news of evolutionary neuroscience and genetics research
author: Peter Loman
source: Radbod University
communication: Peter Loms – Radbod University
image: The image is attributed to news of neuroscience
The original search: Closed access.
“Reproductive and cognitive patterns in vector variables causing recessive pathogensBy Christian Gilison and others. The nature of human behavior
a summary
Reproductive and cognitive patterns in vector variables causing recessive pathogens
The genetic scene of human delegate diseases is formed by mutation and choice. Although the selection of heterogeneous zigut is firmly firmly in the dominant disorders of cars, the convincing evidence of choice in the causes of pathogens associated with recessive conditions is limited.
Here, we have studied insecure pathogens in 1929 gene, which cause recessive diseases when dual ally, in N= 378,751 European individuals are not relevant from the UK’s biological bank.
We find evidence indicating the effects of fitness in heterogeneous tankers of recessive genes, especially for variables in genes restricted through a wide range of diseases.
Our data indicates the reproductive effects at the population level, and thus natural selection, to the changes of diseases that contradict cars.
Moreover, the variables in genes that lie behind mental disability are associated with a decrease in educational achievement in the carriers, and we note a changing genetic scene, characterized by a three -fold decrease in the calculated frequency of dual -pain disability in the population relative to other repeated disorders.
2025-05-15 21:18:00
