He returned back around the vibrant clock in your mind to reduce Alzheimer’s risk star-news.press/wp

summary: The researchers discovered that the “era of biological support for a person”, which reflects how cells produce energy efficiency, and strongly expect the risk of Alzheimer’s disease and its development. High blood levels of the molecules called Aseel Carnitine and the signs of aging metabolism were associated with the fastest cognitive decrease and major symptoms of Alzheimer’s.

However, lifestyle options such as vegetable diets and regular exercises can effectively reduce these molecules, which reduces biological age and may delay the beginning of Alzheimer’s. This vital approach can help identify individuals at early and provide personal strategies to maintain brain health without relying only on medications.

Main facts:

• Bibuli: High levels of Asilartin refer to an older biological era, which is largely linked to Alzheimer’s dangers.
• Lifestyle benefits: A healthy life, including diet and exercise, can reduce vital life, which may provide preventive benefits similar to Alzheimer’s drugs.
• Personal protection: About 30 % of the study participants who suffer from genetic risks, but favorable biological features may particularly benefit from lifestyle interventions.

source: Will Cornell University

New research for young people can be “biological nija” – or how their young cells generate energy – a major indication of whether it is at risk of developing Alzheimer’s disease, as a new research from Will Cornell Medicine shows.

The study, published on February 24 in Nature CommunicationsIt suggests that a healthy life can restore the vital clock for some people, which helps them to formulate Alzheimer’s disease effectively such as a new drug called Lecaneemab.

“This is very large because it means that some people can reduce their risks without the unconfirmed side effects of the current treatments,” said Dr. Jean Kromsic, Associate Professor of Biochemicals and Biochemistry at the Institute of Biomedical Medicine in Medicine and Will Cornell. The first author of the study, Dr. Matthias Arnold, is the head of the arithmetic neuroscience team in Helmhulholz Munich.

The new results bring us a step to a long -term puzzle solution. One of the early warning signs of Alzheimer’s disease is that brain cells begin to lose their ability to produce and use energy efficiently, such as glucose metabolism (sugar). But some people do not show symptoms of the disease for years.

This delay between distortions in energy paths and the beginning of symptoms indicates that there is a “biological capacity” that provides a temporary store for these individuals. Their bodies and brains are better in maintaining energy levels even when problems begin.

“In these cases, people can be unusually healthy when we look at their perception,” said Dr. Kromsic, a member of the England Institute of Exact Medicine. “They reach old age without a kind of declines that are usually crawl.”

But can researchers identify individuals who suffer from these beneficial biological capabilities and help those who do not have it?

A new tool to predict the dangers of Alzheimer’s

Dr. Kromsic and his colleagues have turned into a group of molecules called Asili Carnitine, which are linked to the rejection of perception and the breaking of fats, proteins, and independent proteins or metabolism.

To test if the high levels of Asilartin in the blood can predict the risk of Alzheimer’s disease, the researchers used data from a wide -ranging study called the Alzheimer’s nervous imaging initiative.

“It was great,” said Dr. Kromsic.

“The division of research participants into groups is highlighted based on the levels of Aseel Carnitine specified for people with the most severe Alzheimer’s and other less symptoms.”

This has led to researchers around the clock biological documents based on Asyrinin – how old is a person’s metabolism, compared to the actual age. Biological advanced age is higher at higher levels of acelain, the exacerbation of Alzheimer’s disease, cognitive decline, and brain atrophy.

The researchers also estimated the cognitive decrease using a joint test called the mini -state examination, in which the result is less than 24 of 30 points to twice.

They were found that people with low levels of acilantin to start with a more slowly decreased, and lost about 0.5 points less annually than people with high levels of acilarinin. The interest is equal with Alzheimer’s drug lecanemab.

Dr. Kromsic explained that around the clock for the biological person, it extends around the vital clock of the person forward at a rate determined by genetics, but it has a healthy lifestyle-for example, eating a diet based on the plant and its practice-it can help maintain the levels of ascrianeine low, which means a biological era younger.

They continued to identify a sub -group of participants, about 30 % of the Alzheimer’s neurological imaging initiative, with an old but old but genetic background.

These individuals may benefit more than early lifestyle interventions designed to reduce their vital age and possibly delay or prevent the appearance of Alzheimer’s disease.

The following steps

Moving forward, Dr. Kromsic hopes at the homeland the most effective lifestyle interventions to reduce biological age. For example, eating a low -carb diet may help maintain metabolism, but to what extent should the consumption of carbohydrates for a person see the benefits?

The study also indicates an inexpensive fast test that can specify a person’s ascalantin levels.

“It is fortunate that these blood tests – which have been developed in general to determine metabolic and mitochondria disorders in newborns – can also help assess the life of the vital person,” said Dr. Kromsic.

“If we can re -display this technology for the elderly, this may provide a way to start personal treatment early.”

About this vital era and news of Alzheimer’s disease

author: Barbara Prem
source: Will Cornell University
communication: Barbara Prempeh – Will Cornell University
image: The image is attributed to news of neuroscience

The original search: Open access.
“Individual biological ability as a possible source of flexibility for Alzheimer’s diseaseIn Jean Chromsic and others. Nature Communications

a summary

Individual biological ability as a possible source of flexibility for Alzheimer’s disease

Poor glucose absorption in the brain is early symptoms of Alzheimer’s (AD), with symptoms free from the different period, which are likely to reflect individual differences in metabolic elasticity.

Systemic “biomed” suggests the individual ability to maintain energy balance under pathological conditions.

Using the features of the articulated fasting from the AD nervous imaging initiative as blood -based categories for this capacity, we have identified sub -groups with clinical presentations and a distinctive biological mark of M.

Our data indicates that improving beta oxidation can tamper with biomed aging and disease development.

The effects of treatment for targeting vital ability were similar to those of the newly approved anti -amydid treatments, especially in individuals with genetic patterns of mitochondria associated with metabolism of the carnicin.

Combating, our results provide evidence that biological health promotion may reduce the risk of advertising.

Moreover, biomedia monitoring can be achieved by doll ascalantin measurements using existing clinical checks.