summary: A new study shows that the nicotine management in the long run is reprogramming the metabolism associated with aging and slows down the decrease in the mice. By targeting the sphingolipid power axis, nicotine improved energy balance, the diversity of preserved microbial intestine, and supporting muscle nervous elasticity.
The phenotype treated mice are biological smaller on the basis of an integrated behavior analysis and metabolism. The results indicate that the molecular paths of nicotine may inspire the design of the non -destructive vehicles to enhance healthy aging, although the long -term safety in humans is still unlawful.
Main facts
- Metabolic programming: Nicotine changed glycolipid and sphingolipid paths, and improving energy balance.
- Engine protection: Mice on nicotine showed delayed lower -related engine and a biological definition file.
- Therapeutic capabilities: The results may direct the development of the most secure and non -destructive choline rates of aging interventions.
source: Seat
Aging is a methodological process characterized by an energy imbalance and a decrease in organic metabolism, with the appearance of the engine deterioration as a major component in weakness. With the progress of the world, the challenges remain in healthy aging.
Nicotine is the vital active compound in tobacco. Smoking accelerates metabolic and cardiovascular diseases. However, epidemiological studies indicate that smokers have less risk of some neurological degenerative disorders such as Parkinson’s disease. It is not clear whether the nicotine itself can affect the paths of aging.
In a study published in Advanced scienceA team led by Professor Leo Shenan and Professor Chen Zoxin at the China’s Chinese Academy of Science Academy, along with collaborators, proved for the first time that a lifetime oral nicotine management is reprogrammed with aging.
A 22 -month longitudinal experiment was conducted to study the effects of nicotine throughout life throughout the mice. Moderate or high doses of highly purified nicotine have been added to drinking water to imitate plasma concentrations in human smokers, but without the secondary products for combustion.
The systemic effects of nicotine are set on aging through 3D behavioral tracking (3D), multi -organizational metabolism, microbiota bowel sequence, and cell -based grace.
The researchers have discovered that nicotine re -programming metabolism associated with aging in a dose -dependent manner, especially through glycolibide and Sanklidide paths.
These changes have strengthened the availability of dinotiotide from nicotinamide, limited ceramide accumulation, and improving energy balance, which are molecular adaptations related to the late decline of kinetic.
The analysis of microorganisms has revealed the longitudinal intestine about the preserved microbial diversity and the enrichment of the indexes associated with the race associated with the prevention of sarcopine. By integrating behavioral definition files and metabolism, the researchers developed the degree of “behavior age”, and confirmed that nicotine treated mice showed the younger -to -aged pattern biological.
This study provides the first systemic mapping to re -display nicotine -based metabolism during natural aging, and determines the intestinal energy axis behind the elasticity of the kinetic function.
It makes the long life evaluation, dependent on the dose of the nicotine effect, merges the 3D behavioral data based on artificial intelligence to measure biological aging, and provides an insight into a sphingolipid.
Researchers note that although oral nicotine in this dominant model avoids combustion -related heavens and may pose less systematic risk of traditional tobacco products, their long -term safety and complex biological effects require careful evaluation.
The study provides a mechanical framework for nicotine exposure to long -term exposure and inspiration for “non -destructive metabolism” that aims to maintain mobility and metabolic health in the advanced population.
Depending on years of experience in metabolism, neuroscience, and inhalation materials, the research team will continue to conduct systematic research and a future to detect the scientific basis and the potential value of nicotine as well as new air compounds in aging and metabolic health.
About this aging, nicotine and encyclopedia research news
author: Qun Lu
source: Seat
communication: Qun Lu – SIAT
image: The image is attributed to news of neuroscience
The original search: Open access.
“Nicotine reprogramming the metabolism associated with aging and protects from the decrease in the mice“With lunch, Shane and others. Advanced science
a summary
Nicotine reprogramming the metabolism associated with aging and protects from the decrease in the mice
The effects of nicotine on the kinetic decline associated with aging and controversial are still due to limited experimental evidence.
Here, mice are allowed to consume nicotine over the period of 22 months and notice a decrease in mitigating mobility without pathological changes in the peripheral organs associated with metabolism or immune system defects.
The metal -organized metropolitan stereotypes and network analysis of the elderly mice (24 months) have determined the nicotine paths related to glycolipid metabolism and energy balance.
The accurate stereotypes of the dynamic intestine through a longitudinal chain based on the expression of the chain is revealed that the consumption of nicotine preserved for preserved microbes and changing the microbials from the microbes associated with the path of savingolibide, known as organizing the muscles associated with age and Sarcopenia.
Examinations in the elderly mice and C2C12 cells confirmed that nicotine regulates the rotation of the Sphengolibide, especially through the births of the Svinjliline and the neutral sphingomyelinses, to enhance the availability of dinotiotide adenine, nicotinamide and energy metabolism.
These metabolic adjustments are linked to reduced ceramide accumulation and improved engine function. The BMAGE degree has confirmed the virtual pattern of biological aspects in nicotine treated mice.
These results indicate that nicotine metabolism is lifelongly reprimanding aging metabolism by organizing the system of the system, which gives flexibility against age -related motor depression.
2025-08-21 17:01:00
