summary: Unlike most tissues, the retina does not call fornearies – the first typical respondents of the body – when it was injured. Instead, small glial cells, immune cells residing in the brain, deal with damage to light receptors without calling for backup.
Using adaptive visual imaging, researchers noticed this unique immune behavior in the retina living retina. Results indicate a protective “hiding” mechanism that prevents excessive inflammation and future treatments for visual loss may be learned.
Main facts:
- Eye retina response: Novers do not help repair light receptors despite being nearby.
- Activating small glial cells: Only the immune cells residing in the brain respond to the injury of the retina.
- Inflammation Shield: The retina may suppress the recruitment of immune cells to prevent further damage.
source: Rochester University
During most eye infections or injuries, neutrophils are usually, the immune cells in the blood, are the first line of defense.
However, researchers at the Flaioum Eye Institute and the Del Monte Institute of Neuroscience at the University of Rochester discovered that the retina responds differently from many other tissues in the body.
When light -light cells are damaged in the retina, immune cells are not recruited in the brain, and neutrophils are not recruited to help despite passing through nearby blood vessels.
Jesse Chalik, associate professor in ophthalmology and author of the first study of today’s study Elife.
“This relationship between groups of main immune cells is the basic knowledge because we build new treatments that must understand the difference of immune cells interactions.”
Using adaptive visual imaging, the camera technology developed by the University of Rochester allows the photography of single neurons and immune cells inside the eye of the live, the researchers studied the retina from the mice with damage to light receptors.
They found that although both of the neutral cells and small glial cells are in the retina, small glial cells only respond only to a light -receptor injury, and neutrophils are not invited to help repair the damage of light receptors.
The researchers believe that this indicates a kind of concealment during the retina injury to protect the retina from the impulsion of immune cells that can cause greater harm.
“What is noticeable here is that passers -by are very close to the interactive small glial cells, however they do not refer to them to help recover damage,” Shalik said.
“This is significantly different from what appears in other areas of the body where the necks are the first to respond to local damage and install an early and strong response.”
Light background cells are unique in the retina. They process light in electrical and chemical signals, and they connect this information to our brain, allowing us to see.
There are many diseases that harm and kill the cells of light receptors, including age -related macular degradation, retinitis dyeing, urging conical atrophy, and currently, there is no treatment.
This research now shows that it is possible to imagine the dynamics of the single cells because they communicate with each other, as the retina responds to damage.
The first author, Derek Power, a laboratory technician in the Shalik Laboratory, led the study. Among the other authors are Justin Elsutrot, PhD, from Genentech Inc.
Finance: The research has been supported by the National Eye Institute, research to prevent blindness, Dana Foundation, and a cooperative research grant from Genentech, Inc.
On this news of this visual neuroscience research
author: Kelissy Smith Hydewock
source: Rochester University
communication: Keelsey Smith Hydoc – Rochester University
image: The image is attributed to news of neuroscience
The original search: Open access.
“A light future loss does not recruit neutrophils despite the strong delicate stimulationBy Derek Power and others. Elife
a summary
A light future loss does not recruit neutrophils despite the strong delicate stimulation
In response to the infection of the central nervous system (CNS), the residing immune cells of the tissue such as small glial cells and systemic cells are often answered first.
The degree with which these cells interact in response to the damage of the central nervous system is not well understood, and even less, in the nerve retina, which is a challenge to high -resolution imaging in the live body.
In this study, we spread the adaptive optics of the light survey (AOSLO) to study the small glial cells and the values in the mice.
We follow the dynamics of the immune cells simultaneously using the sticker -free mutual AOSLO. Meccan lesions were created with light 488 nm focusing on light -receptor clips (PR).
These pests empty PRS, with minimal side damage to the cells higher and under the concentration level.
We used in Vivo Aoslo, and the optical cohesion (OCT) to detect the natural date of the accurate residences of the neutrophils and necks from minutes to months after the injury.
While small glial cells showed a dynamic and progressive immune response with cells that migrate to the site of the injury within one day after injury, neutrophils were not recruited despite the proximity to the vessels that carry neutrophils just a micron away. The microscopic microscope was confirmed after death in the results of the live body.
This work shows that MicroGlial does not recruit neutrophils in response to the acute and focal loss of PRS, which is the condition of its confrontation in many retinal diseases.
2025-07-24 20:07:00
