summary: Adolescence is a critical period for the front shell of the brain, where the executive functions and the weak citizen are ripen for mental disorders. A new study showed that small glial cells, brain immune cells, directly form dopamine circles during this time by enhancing axial communications.
Surprisingly, MicroGlial communication occurs before new bots are formed, highlighting its role in the elasticity of the circle. These results indicate potential treatments for growth and psychological nervous disorders by targeting the activity of small glial cells during adolescence or even reactivating it in adulthood.
Main facts
- The role of small glial cells: Brain immune cells strengthen dopamine circles during adolescence.
- Critical window: The development of the abnormal front shell in adolescents can lead to disturbances such as schizophrenia and ADHD.
- Therapeutic capabilities: The drug may help along with activities such as exercise to restore the plasticity in adult brains.
source: Rochester University
Making juice, going on an evening picnic, or sympathy for a member of his family, are all examples of the executive functions that are controlled by the front shell of the brain.
This region of the brain passes through a deep change throughout adolescence, and during this time it can distort in mature circles that can put the way for nervous growth disorders, such as schizophrenia and ADHD.
Researchers at the Del Monte Institute of Neuroscience at the University of Rochester have discovered that the immune cells in the brain and immune cells in the brain play a major role in how the brain adapts to changes in this field during adolescence, which may prevent how neurological disorders are treated during this window, and perhaps, in mysterious.
“The best understanding of the methods through which we can make changes in these circles provides new targets for the treatment of diseases,” said Ryan Stoyel, a professor of neuroscience at the Rochester University Medical Center, and the first author of the study study today in his “studies”. Nature Communications.
“This area is subject to change, whether good or bad, during adolescence. The previous work in our laboratory has found that both the direct activation of the front dopamine circuits and the rewarding behavior that pushes the plasticity from dopamine bonds to the front crust during adolescence, but not the age of adulthood.”
The immune cells support the connection of the circle
Dopamine circuits in the brain consist of networks of neurons that use dopamine to send information. These circles are necessary to regulate brain function, including movement, motivation and perception.
An exercise, or the wheel that works for mice, is a natural and rewarding experience that activates the front dopamine circle. Using this model and optical material, a technique that uses light to control the genetically targeted neurons, the researchers note that small glial cells in the live brain are recruited in the front dopamine circle in adolescent mice.
Small glial cells responded to activating dopamine by contacting the axes, the long part of neurons that work like cable transmission signals, then new bots formed along those axes. Putonat are parts of neurons that transmit signals to other cells.
According to Stowell, this explains that small glial cells have a direct effect on increasing dopamine circuit. Basically, the brain’s immune cells appear to play a major role in strengthening the brain network.
“We were surprised to see accurate contact with a nervous axis that occurs before the formation of a new botton,” said Stwell. “This research indicates that small glial cells are very sensitive to dopamine’s activity, and there is a convincing relationship between MicroGlial and structural changes in a nervous axis.”
Finding a goal in the brain of adults
Research at the Wang Laboratory has shown that the administration of the dopamine D2 receptors, Quinberol, is prohibited from plasticity in adolescence. On the contrary, giving antylylopride – an antipsychotic drug – to extreme mice re -employed small glial cells into neuropathic axes and has strengthened the formation of a new bottleate.
Stop said that future research will explore whether the combination of drug treatments with dopamine stimulation, such as exercise, can help treat mental disorders affected by a deficit in this field of the brain.
“We now want to determine, at the molecular level, what the exactly small glial cells do inside the circle. For example, how it affects the growth of bottonat,” said Stwell.
“We will use the pharmaceutical manipulation of specific microGlial signals systems in addition to the one cell sequence for drilling in what makes this circle flexible during adolescence but not puberty.”
Kwan Hong Wang, PhD, Professor of Neuroscience, Pharmacology and Physiology at the Rothschester Medical University Center, was a major author of this study.
Finance: This research was supported by the National Health Institutes and an experimental grant from the Del Monte Institute for Neuroscience.
On this news of this neurological development research
author: Kelissy Smith Hydewock
source: Rochester University
communication: Keelsey Smith Hydoc – Rochester University
image: The image is attributed to news of neuroscience
The original search: Open access.
“Dopomine signals organize Microglial and teenagers in the mouse front shellWritten by Ryan Store and others. Nature Communications
a summary
Dopomine signals organize Microglial and teenagers in the mouse front shell
Adolescence is a sensitive period for anterior cortical development and cognitive maturity, characterized by the increasing structural code in the dopamine intermediate circle (DA).
However, the cellular and molecular mechanisms behind this plasticity are still unclear.
Here, we show that small glial cells, fungal immune cells of the brain, are very response to medium DA signals during adolescence.
Lental photography in the vocal body of the fungus in mice reveals that the front cortical microorganisms increase the monitoring of the DA axials after rewarding experiences or the optical stimulation of the DA axes.
The accurate contacts with DA axes are constantly preceded by the formation of Botton, and small glial cell reactions are organized by D1 and D2 receptors in adolescence and adulthood.
Moreover, MicroGlial P2RY12 receptors are necessary for micro -monitoring and the formation of Da Bouton during adolescence.
These results reveal the two -way reactions between the DA signals and the accurate monitoring that pushes the front plasticity of adolescents and set the potential targets to restore the plasticity in adulthood.
2025-08-28 13:09:00
