summary: A new study showed that mice, such as humans, can face an embodiment towards one of the artificial limbs, similar to the famous illusion. When their real limbs were hidden and the real and false parties were ignored, mice tracked a visual threat to the fake limbs, indicating the perceived ownership.
This discovery creates a strong new animal model to explore the brain mechanisms of the body’s property and embody the artificial limbs. It can pave the way for advanced neurons and treatments for cases such as the pain of fake ends or the hardship of the body.
Main facts:
- Illusion rubber rodents: Mice responded to threats against fake ends when the practical and visual sermon was synchronized.
- The visual tracking shows an embodiment: The mice focused longer on the artificial end under threat when they match with them and moved simultaneously.
- New research form: This study provides the first practical rodents model for the study of body ownership and artificial integration.
source: Plos
Mice can develop a sense of embodiment of a siphY In the open access magazine Biology Plos Written by Luc Estebanez from CNRS: National Center for Scientific Research, France and its colleagues.
We imagine our limbs as part of ourselves, and we feel threatened with any threat to them. This sensation of embodiment can be disabled due to brain injuries, which leads to the loss of recognition of the parts of the body, and even its active rejection of the body’s representation.
In the case of patients who have been amputated, the effective use of the artificial extremities can hinder the lack of artificial embodiment, causing a gradual decrease in the use of daily artificial extremities and finally the abandonment of the end -of -end limb.
On the other hand, the embodiment of prostheses is associated with a decrease in the sensations arising from the lost ends, including painful perceptions.
In an experimental environment, it is possible to either build or disable the feeling of embodiment of the artificial limb by addressing the coincidence of the optical stimulus.
In particular, in the experience of the rubber delusion, a rubber tip is placed in a position that makes it visible to the participant, while the real hand is hidden from view. Each of the real hidden hand and visible artificial hand are hit in conjunction with a brush.
A large part of the topics in these experiments indicate that after this stimulation, the rubber hand they see is their true hand. To date, the physiological rules of the sensory Forelimb embodiment are still unclear, in part due to the lack of an animal model for studying the embodiment.
To address this challenge, Estepenese and his colleagues developed a representative of the elastic illusion protocol of mice.
The researchers presented the mice installed on his head with a right -fly version of the right Forelimb at a reasonable physiological location. At the same time, the real Forelimb was hidden from view and stuck to its place under the platform where the artificial end was present.
During the two -minute conjugation sequence, the researchers applied coinciding or simultaneous brush strikes mechanically to real places and writing. Then the researchers dropped a sharp body towards the artificial front that was observing the animal.
During this sequence, mice looks were tracked using high -speed video. Looking at the broader literature on the rubber delusion, the mice focused their view of the threat for several seconds when the brush strikes were synchronous, but not when they were uninterrupted.
The behavioral response was also stronger when the artificial Forelimb looked similar to the ends of a white -shaped white object.
According to the authors, this work has practical effects to study Forelimb’s embodiment in a model that offers unparalleled experimental places. For example, the appointment of brain circuits for embodiment using genetic and visual research tools can lead to new restoration strategies.
Moreover, the research also supports the idea that rodents can display behavioral connections to the embodiment of the known settings that lead to the embodiment of humans. This adds to a series of modern results that indicate that rodents and mice in particular can display some capabilities associated with higher cognitive functions.
The authors add, “The illusion of the rubber hand is an essential element in studying the representation of the body in humans, but there has been no equivalent to this test in the most executive model: mice.
“We have shown here that the embodiment of the limbs can be operated and measures efficiently in mice.
“This opens many opportunities to better understand the basic mechanisms of ownership of the body and apply them, for example, to improve the artificial extremities.”
Finance: This work is funded by PRC Hermin, Anr. LE, JCJC Mesobrain, Anr. Le, PRC expect, anr. Des, PC Perbaco, Anr. Des ,, 3ds Foundation, 80 | PRIME 2020, CNRS, LE and AC, Miti Prime 2024, CNRS, LE and AC, PRC Motorsense, Anr. Ve, Rise Inavigate, 873178, Horizon 2020 Framework Program. Des, OI HCode, University of Paris Squli, Lu.
The financiers did not play any role in the design of the study, collecting and analyzing data, preparing the manuscript, or Du Publish decision.
About news of nervous science and neuroscience
author: Claire Turner
source: Plos
communication: Claire Turner – Plus
image: The image is attributed to news of neuroscience
The original search: Open access.
“The embodiment of an artificial tip in miceBy Luke Estepes and others. Biology Plos
a summary
The embodiment of an artificial tip in mice
It can cause body ownership disorders due to disease or body damage. Ways to investigate the embodiment of the limbs are needed to address these disorders. This includes the development of neurons that are better integrated into the user’s body scheme.
To achieve this purpose, the protocol “the illusion of rubber hand” is a major behavioral method of investigating strong embodiment that can occur by physical and visual sensory inputs from the party.
Until now, neural physiology of the embodiment of the limbs is still badly known, partly due to the translation of the rubber hand into animal models such as mouse is still difficult.
However, the appointment of brain circuits for embodiment thanks to the use of genetic and visual research tools would allow the proposal of new embodiment restoration strategies.
Here, we make it clear that the illusion of the rubber hand described in humans can be translated into the Forelimb model of the mouse using an automatic video action.
We have revealed the fixed mice of the head to the right -visible printed version of the right Forelimb, while their Forelimb has been hidden from their eyesight. We have followed the invisible Forelimb and the symmetrical version.
After these tactile visuo associations, the symmetric version was visually threatened, and we investigated the reaction of mice using the automatic tracking of students and face expression.
The mice greatly focused more than their view of a threatened Forelimb replica after receiving simultaneous touch and visual touch information compared to the inaccurate.
Dresses, through test conditions and control, the response of the mouse pupil was consistent with the human public response to the illusion of the rubber hand.
Thus, our results show that mice show quantum measurable behavioral signs to embody the artificial front.
2025-06-05 20:56:00
