summary: Speaking requires an accurate sequence of muscle movements, and it has long been believed to be coordinated by the Broca region in the brain. New research reveals that a different area, the Middle Every (MPRCG), plays a major role in planning and implementing the speech sequence.
Using brain and stimulus records during surgery, scientists have shown that MPRCG activity increases with the complexity of speech and errors arise when disabled. This discovery opens new ways to understand speech disorders and develop auxiliary communication technologies.
Main facts:
- MPRCG helps in a series of speech sounds together in words, which is previously attributed to the Brooka region.
- Activity in MPRCG scales with the complexity of the operative clip sequence.
- MPRCG disrupts while simulating speech, confirming its decisive role.
source: Ucsf
Speaking is one of the most complex things a person can do. Before you say one word, your mind must translate what you want to say in a completely consecutive group of instructions into dozens of muscles that you use to speak.
For more than a century, scientists believed that all this planning and coordination-called the speech sequence-event-event in part of the frontal lobe called the Brooka region.
Now, a new study from the University of California in San Francisco showed that it depends on a broader network of neurons across many regions of the brain. This network is concentrated in an area called the Middle Every, or MPRCG, which scientists may only control the throat, which is part of the audio canal that helps us make high or low sounds.
“It turns out that this part of the brain has a more interesting and important role,” said Edward Chang, head of neurosurgery, and author of the study. “It combines the sounds of speech to form words, which is very important to be able to pronounce them.”
The study that appears on July 16 in The nature of human behaviorIt can inspire new ways to consider speech disorders, help develop devices that allow paralysis to communicate, and help keep the patient to speak after brain surgery.
Beyond Brooka
The Brooka region, which was called the world of physiology, Pierre Paul Brooka, which he discovered in 1860, is believed to deal with most of our language treatment. This includes both how to make the language we hear or read, and how we produce the words we intend to say.
But several years ago, Zhang, a member of the UCSF Weil Institute for Neuroscience, has spent more than a decade in exploring the issue of how the brain is produced, and is suspected that it includes areas that exceed Broca.
In a rare case study, he saw that when the patient had a tumor of MPRCG, they developed Aprlyxia of speech, a condition in which people knew what they want to say, but they are struggling to coordinate the necessary movements for saying clearly. The same condition was not caused by similar surgeries in the Brooka region.
Zhang and postgraduate student Jesse Leo also noticed his doctoral activity associated with MPRCG speech planning while developing a device to allow paralysis people to communicate.
To investigate what was happening, Chang, Liu, and the researcher after the Lingyun Zhao doctorate, with a doctorate, with 14 volunteers undergoing brain surgery as part of his treatment for epilepsy. Each patient had a thin network of electrodes placed on the surface of their brain, which could record the brain signals that occur before they spoke their words.
Nerve surgeons, such as Chang, are routinely used by these electrodes to help them set the place of seizures in the patient’s brain. If there are speech areas nearly, the surgeon will also plan them, to avoid destroying them during surgery.
Leo and Zhou managed to appear on technology to find out what was happening in MPRCG when patients were speaking.
They showed that volunteers are sets of clips and words on the screen and then asked them to make the sounds loud. Some groups were a simple, repeated clip, such as “Ba-Ba-BA”, while others included more complicated sequences, such as “Ba-Da-Ga”, which contains a variety of sounds.
The researchers saw that when they gave the participants more complicated sequences, MPRCG was more active than it was at the time when the participants were given. The team also found that the increase in the activity in that region predicted the speed in which the participants will start speaking after reading the words.
Liu said: “Seeing this mixture – working with a greater effort to plan a more complex sequence and then muscle signals to put the plan into effect – tell us that although MPRCG is outside the Brooka region, it is important to coordinate how we talk.”
Link the intention to work
The team also used the electrodes to motivate MPRCG in five study participants while they are pronouncing a set of clips.
If the serials are somewhat simple, the participants did not have a problem. But when they were given more sophisticated sequences, stimulation caused the perhaps -like errors in his study study.
This adds more evidence that MPRCG is essential to coordinate various different speech sounds and works as a bridge that connects what a person wants to say with the procedures required to say that.
“He plays this vital role that he believed to belong to the Brooka region, but he was not completely appropriate there,” said Liu. “This indicates to us in the direction of a new research, where he learns how MPRCG has a new understanding of how to speak.”
Finance: This work is funded by NIH (R01-Dc012379) and charitable work.
About this news of this neuroscience and neuroscience
author: Robin Marx
source: Ucsf
communication: Robin Marx – Ucsf
image: The image is attributed to news of neuroscience
The original search: Closed access.
“Speech sequence in pre -human human conditioningBy Edward Chang and others. The nature of human behavior
a summary
Speech sequence in pre -human human conditioning
The mediation is fluent in the production of speech by requesting and preparing the plans of the kinetic corresponding to the sounds of the targeted speech, a process known as the speech sequence.
Here we used high -dense direct cortical records, while 14 participants talk about words with a variety of audio and sequence after reading a targeted sequence and a delay period.
The stimulants were observed that corresponding to the production of speech and auditory comments, but also the continuous nervous activity that continued at all stages of tasks including the targeted presentation, the delay and the production of sequence.
Moreover, the ongoing activity was modified in a specific area, the Middle Every (MPRCG), through the complexity of the sequence and the time of the expected interaction, indicating a role in the speech sequence.
MPRCG is caused by speech optimism that resembles those seen in April of speech.
These results indicate that the kinetic sequence in speech is carried out by a distributed cortical network in which MPRCG plays a central role.
2025-07-16 21:02:00
