Cold ulcers associated with Alzheimer’s disease may reduce antivirals star-news.press/wp

summary: A major study indicates that the symptoms with the HIV 1 (HSV-1)-known to cause cold sores-significantly arouse the risk of developing Alzheimer’s disease. The researchers found that people with HSV-1 were 80 % more vulnerable than Alzheimer’s disease, while those who were treated with antiviral drugs had 17 % less risk.

The results are in line with other evidence that HSV-1 may lead to inflammation and the accumulation of beta amyloid in the brain, and signs of Alzheimer’s diseases. Although the study is observation and cannot prove the causal relationship, it highlights the possibility of antiviral treatment as a preventive strategy and urges to focus on public health on the prevention of herpes virus.

Main facts:

• 80 % higher risk: HSV-1 people were more likely to develop Alzheimer’s disease.
• Useful antiviral: HSV-1 patients who took antiviral drugs had 17 % risk of Alzheimer’s disease.
• Biological link: HSV-1 may push brain inflammation and amyloid accumulation, which contributes to dementia.

source: Bmj

The symptoms with the virus responsible for cold sores around the mouth-or HSV-1 for a short period-may be a major role in the development of Alzheimer’s disease, that a major American study funded by the pharmaceutical industry published in Access Open BMJ is open.

But it seems that antiviral therapy is associated with a lower risk of this type of dementia, indicating that the treatment for the suppression of HSV-1 symptoms may be preventive, as the results indicate.

Currently, researchers live that about 35.6 million people worldwide live with dementia, and 7.7 million new cases are diagnosed every year, the researchers say. And they add and add that Alzheimer’s disease includes 60 % – 80 % of all dementia, with total costs for their treatment of up to $ 305 billion in 2020.

Many infectious factors have been involved in the development of Alzheimer’s disease, the most lesson of these factors are HSV-1, which affected more than two thirds of less than 50 years around the world in 2016 alone.

To shed more light on the HSV-1 arrest role in Alzheimer’s disease and the potential preventive anti-anti-drug effects, the researchers relied on a wide range of American administrative claim data (IQVia Pharmetrics Plus) for the 2006-21 period.

People with Alzheimer’s disease have been matched with age, sex, geographical area, the entry year of database and the number of health care visits with those who have no history of neurological diseases, resulting in a total of 344,628 pairs of cases and control.

Nearly two -thirds of (65 %) of those with Alzheimer’s disease were women. The average age was 73 years and they tended to get more coexistence conditions-all risk factors.

In general, 1507 (less than 0.5 %) of Alzheimer’s disease with HSV-1 (0.44 %) compared to 823 (less than 0.25 %) of the comparison group (control).

It is not surprising, the risk of Alzheimer’s disease increased along with age. However, in general, the possibility of HSV-1 diagnosis was 80 % higher among those who suffer from Alzheimer’s disease, after controlling potential effective factors.

Of the 2330 people with HSV-1 infection, 931 (40 %) used anti-anti-anti-drug drugs after being diagnosed. They were 17 % less likely to develop Alzheimer’s disease than those who did not use these treatments.

The researchers also looked at the potential role of herpes viruses, including HSV-2, the virus of the virgin and the cell virus. Both HSV-2 and Varicella Zoster infections were associated with an increased risk of Alzheimer’s disease.

Exactly how HSV-1 and other nerve viruses may increase the risk of dementia are not clear, the researchers explained.

“However, studies have shown that inflammatory changes in the brain caused by HSV are pivotal in the development of (Alzheimer’s disease),” they explain.

“Aβ peptides deposit in response to HSV infection and the protection of host cells were reported by preventing viral membrane with plasma membrane, referring to HSV as a potential risk factor for Alzheimer’s.

HSV-1 DNA is also found in the distinctive Alzheimer’s paintings, and people with APOE ε4, which is the most common genetic risk factor for the disease, more vulnerable to HSV infections, as they notice.

This is a monitoring study, and in this way, strong conclusions cannot be extracted on cause and influence. The researchers admitted that the HSV-1 infection before the patient was inserted into the database was not known, in addition to any of the people who suffer from infection have no symptoms, while others may not ask for treatment when they do all factors that may affect the results.

But the results they reached are in line with other studies. They suggest: “While molecular mechanisms remain fully illustrated, these results indicate a potential role for anti -treatment treatment in relieving the risk of dementia.”

They concluded the following: “These results focus more on the display of herpes viruses as a priority for public health.

About Alzheimer’s research news

author: Emma Dickenson
source: Bmj
communication: Emma Dickenson – BMJ
image: The image is attributed to news of neuroscience

The original search: The results will appear in BMJ is open