summary: New research reveals that men who carry two copies of a common genetic variable in the HFE gene are more than twice that are likely to develop dementia, while women who suffer from the same alternative are not affected. The variable, known as H63D, is associated with blood blood and is present in about 1 in 36 people.
Interestingly, researchers did not find any direct link between high iron levels and the risk of dementia, indicating instead to other biological mechanisms such as inflammation or nerve damage. These results can direct strategies for preventing dementia, especially for men who carry this gene.
Main facts:
- Sex risk: Men who have two copies of the H63D gene variable have twice the risk of dementia. Women do not.
- Beyond iron levels: It seems that the increased risk has nothing to do with iron in the blood, indicating that the other tracks are involved.
- Clinical capabilities: The routine HFE test can help identify men at risk for previous intervention.
source: Curtin University
New research has found that men with a common genetic variable are likely to have dementia in their lives compared to women.
Search, published in neurologyData from aspirin used to reduce events in the experience of the elderly (ASPREE) to investigate whether people who have variables in blood inflammation (HFE(Jin, which is very important to regulate iron levels in the body, may be more likely to risk dementia.
Professor John Olinic, co -author of Curtin Medical College, said that one in three people carry one version of the variable, known as H63D, while carrying one in every 36 copies.
“The presence of only one copy of this genetic alternative does not affect a person’s health or increases the risk of dementia. However, the presence of two copies of the variable is more than twice the risk of dementia in men, but not women.”
“Although the genetic alternative itself cannot be changed, it is likely that it is likely to treat the brain paths that affect it – which leads to the damage that causes dementia – if we understand more from it.”
Professor Olinic said that more research is needed to investigate the reason for increasing this genetic alternative from the danger of dementia for males, but not females.
“the HFE The gene is routinely tested in most western countries, including Australia, when people evaluate blood inflammation – a disorder that makes the body absorb a lot of iron. The results we find indicate that this test may be presented to men on a larger scale.
“while HFE The gene is very important to control the levels of iron in the body, and we did not find any direct link between the levels of iron in the blood and an increase in the risk of dementia in the infected men.
“This indicates other mechanisms of play, and may involve an increased risk of brain infection from inflammation and cell damage in the body.”
Professor Paul Lacaz, co -author of the University of Monash, said the results can help improve the results of people at risk of developing dementia.
Professor Lacaz said: “More than 400,000 Australians are currently living with dementia, with about a third of them men. They are why men who suffer from the double H63D variable in a higher risk can pave the way for more personal methods of prevention and treatment,” said Professor Lacaz.
“This study is a great example of how to effectively diversify the various Australian research groups and universities to learn more about these progressive diseases and ultimately improve health results for people all over the world.”
The ASPREE experience was a double -blind, random experience, controlling the imaginary drug of low daily aspirin in 19,114 healthy elderly in Australia and the United States of America. It was implemented primarily to evaluate risk against the daily aspirin benefits of the low dose in this group, and has created a treasure of healthy aging data that prompted a wealth of research studies.
The research was a cooperation between the University of Curtin, the University of Monash, the University of Melbourne, the Royal Children’s Hospital, the Children’s Research Institute and the Fiona Stanley Hospital.
About this genetic and dementia research news
author: Yasmine Philips
source: Curtin University
communication: Yasmine Philips – Curtin University
image: The image is attributed to news of neuroscience
The original search: Closed access.
“The genetic patterns of doma and dementia in the future study of older adultsWritten by John Olina and others. neurology
a summary
The genetic patterns of doma and dementia in the future study of older adults
The background and goals
Variables in the symmetric iron regulator (HFE(Jin is spread among individuals of European origin and is associated with an increase in the risk of dementia. This study aims to assess the effects HFE P
road
This potential longitudinal study used data from aspirin to reduce events in the elderly experience. Participants had no history of cardiovascular, dementia, or cognitive decrease in registration. Genetic stereotype for HFE P.Cys282Tyr and P.His63ASP variables were made using microscopic matrices, and virite concentrations were measured in the foundation serum in peripheral blood samples.
Dementia diagnoses have been confirmed by the separation committee on moderate follow -up of 6.4 years. Associations are evaluated using the modified COX relative models of related common variables.
results
The study included 12174 non -relevant participants of European origin between 70 years or older, with 5,583 men (45.9 %) and 6,591 women (54.1 %). The average age was 73.7 years (the quadrilateral range (IQR): 71.6-76.9) for men and 73.9 years (IQR: 71.7-77.5) for women.
Compared to the group of wild type, men with P.CYS282ter+/+ (P = 0.048) and p.cys282tyr +/pP <0.001) Veritan levels were much higher. Women with P.His63ASP+/+ (P = 0.015) and p.cys282tyr+/p.his63ASP+ (P <0.001) Genetic patterns also showed high levels of virite. No significant correlation between Veretin levels was noticed in the basic serum and dementia.
However, men with P.His63ASP+/+ Genetic style had a much higher risk of dementia (modified risk ratio = 2.39, 95 % CI 1.25-4.57,, P = 0.009) Compared to those who do not have HFE Differences. This link was not observed in women.
discussion
Among the healthy adults at first, HFE p These results highlight a possible genetic risk factor for dementia and ensure more research in the basic mechanisms that link P.His63ASP and dementia.
2025-05-30 19:30:00
