summary: Scientists have identified a natural vehicle group that reflects the decrease in brain cells associated with aging and removes the proteins associated with harmful Alzheimer’s. Treatment, which combines nicotinamide (vitamin B3) and anti -oxidant antioxidants, restores the levels of trojhosvasine (GTP) – embarrassment of nervous energy and protein cleaning.
In ancient neurons, restored energy reinforced protein, reducing oxidative stress, and main cell smuggling paths. The results indicate that there is a possible non -drug strategy to combat Alzheimer’s disease, although more work is needed to improve delivery.
Main facts
- Energy restoration: Nicotinamide and green tea have returned antioxidants to GTP levels in old neurons to youth levels.
- Protein removal boost: Treatment improved the brain’s ability to remove toxic amylaid bita.
- Non -pharmaceutical capabilities: The results indicate an attachment approach to prevent Alzheimer’s or treatment.
source: Uc Irvine
Researchers at the University of California, Irvin, have identified a promising non -international treatment that does not wander in the brain cells in the aging of the brain cells and removes the accumulation of harmful proteins associated with Alzheimer’s disease.
In a sheet recently published in the magazine GyroscopeThe UC IRVINE team states that a mixture of naturally occurring compounds – nicotinamide (a form of vitamin B3) and Epigallocatechin Galte (anti -oxidant green tea) – can restore the levels of gewozinian phosphate, which is a basic energy molecule in the brain cells.
In tests on the nerve cells in the dish, the reversal of the cell deficit associated with age and improving the ability of the brain cells to remove harmful amyloid protein groups, which is the distinctive feature of Alzheimer’s.
“As people of their age, their brains appear to decrease in nervous energy levels, limiting the ability to remove unwanted proteins and damaged components,” said lead author Gregory Bruroer, Assistant Professor of Biomedical Engineering at the University of California in Irvin. “We have found that restoring energy levels help neurons restore this critical cleaning function.”
The researchers used a genetically encrypted fluorescent sensor called Givel to track the levels of life triple phosphate in the nerve cells of the typical mice of Alzheimer’s disease. They discovered that free GTP levels decreased with age – especially in mitochondria, cell energy centers – which leads to poor self -devotion, a process that cells eliminate damaged components.
But when old neurons were treated for only 24 hours with nicotinamide and Epigallocatechin Gallate, GTP levels were restored to those that were usually seen in the younger cells.
This revival sparked a series of benefits: improving energy metabolism; Activation of the main GTPASES participating in cellular trafficking, RAB7 and ARL8B; Effective rid of the totals of the amyloid beta. The oxidative stress, the other contributor to nervous degeneration, has been reduced.
“This study highlights an unprecedented energy source that leads the vital brain functions,” Bruer said.
“By completing the energy systems in the brain with already available vehicles as food supplements, we may have a new way towards treating the cognitive decline associated with age and Alzheimer’s disease.”
He warned, “More work will be asked to find the best way to manage this treatment, because a modern clinical trial included UC Irvine researchers that showed that oral nicotinamide was not very effective because of his disruption in the bloodstream.”
The collaborators of Borwer Ricardo Santana, a co -specialist at the University of California at Irvin in biomedical engineering, and Joshua Mac Wrt, a Junior specialist at the University of California at Irvin, is now a PhD. A candidate at South Carolina Medical University.
Finance: Funding was provided by the National Health Institutes and UC IRVINE.
On these nutritional supplements and news of the aging of the brain
author: Brian Bell
source: Uc Irvine
communication: Brian Bell – University of California in Irvin
image: The image is attributed to news of neuroscience
The original search: Open access.
“The treatment of age -related decrease in GTP levels re -inflammationBy Gregory Buruer and others. Gyroscope
a summary
The treatment of age -related decrease in GTP levels re -inflammation
Life -related decreases in nerve energy levels may limit vepilese trafficking and self -clearance of damaged organs and proteins.
ATP exhaustion associated with age affects the perception depends on the ion balance, but the boundaries on the proteins where the GTP operates is less clear.
استخدمنا الخلايا العصبية المعزولة من الفئران النموذجية لزهايمر 3xtg-AD AD Aged ومستشعر GTP الفلوري المشفر وراثيًا (GEVAL) لتقييم مستويات GTP الحية في الموقع.
We report a decrease dependent on age in the Ratiometric measurements of the free GTP levels/tied in lively fortified neurons. Free GTP decreased in mitochondria as ages with the accumulation of vesicles called free GTP.
Energy adoption of self -pharaoh was evident by exhausting the GTP with the stimulation of the Rapamicin, while the inhibition of the bavilium from the self -phagocyto raised the levels of GTP.
Elderly nerve cell supplements for twenty -four hours with Nicotinamide and NRF2 MDULATOR EGCG Braded GTP levels to youth levels, domestic poisoning and Lasosom consumption for self -accumulation via GTPASES RAB7 and ARL8B.
This vesicle mobilization has strengthened AD groups in genetics, improving authority, and lowering the oxidized nitrate of protein in typical neurons AD.
Our results reveal a deficit in the age of age -related nerve and advertisement that weaken self -bonus and inner cells. GTP deficit was treated with external NAD spoilers with Modulator NRF2 RDOX, which indicates a translation path.
2025-08-09 19:53:00
