summary: The researchers have successfully designed the dual mice, born from male and male religion, survived adulthood using embryonic stem cell techniques. By modifying 20 main blurring genes, they overcame the development barriers that were previously shortened to the sexual reproduction in mammals.
Although only 11.8 % of the embryos have been developed in the range, the results highlight broadcasting distortions as a major obstacle to the sexual reproduction of mammals. Research develops regenerative medicine, and provides an insight into diseases related to a process, but there are still moral and technical challenges to expand this work to the greater animals or humans.
Main facts:
- Horization technology: 20 biblical genes have been released from the father’s dual -age.
- Development restrictions: Only 11.8 % of the embryos have reached birth, with many defects that appear.
- Future goals: Researchers aim to extend results to large animals and improve results.
source: Cell Press
A team of stem cell scientists successfully used embryonic stem cell engineering to create a dual-mouse mouse with male parents-which live until adulthood.
Their results, published on January 28, 2025, in Press Cell The cell stem cellDescribe how a certain group of genes participating in reproduction allowed researchers to overcome the challenges that cannot be pre -overrated in sexual reproduction in mammals.
Scientists have tried to create dual -father mice before, but the embryos have only evolved to a certain point and then stopped growing.
Here, the investigators, led by the corresponding author Wi -Lee from the Chinese Academy of Sciences (CAS) in Beijing, focused on targeting genes that regulate the genetic expression in several ways.
“This work will help treat a number of restrictions in stem cell research and renewal,” says Li.
“The unique characteristics of the fingerprint genes have prompted scientists to believe that they are a fundamental obstacle to reproduction of sexual in mammals,” says co -author Chi Chu, from Cas.
“Even when building artificially or artificial dual embryos, it fails to develop properly, and contracts at some point during development due to these genes.”
Previous attempts to make mild mouse mouse uses ovarian candidiasis to derive eggs from male multi -capacity stem cells; Then this hateful was fertilized with sperm from another male.
However, when the symmetrical chromosomes – chromosomes that are divided during the division of the division to create eggs and sperm – of the same sex, organize distortions, leading to severe development defects.
In this study, the researchers modified 20 main fingerprint genes using a number of different technologies, including tire mutations, deletion of genes, and regulatory area editing.
They found that these amendments not only allowed the creation of the father’s dual animals that sometimes live to adulthood, but also led to stem cells with greater stability.
“These results provide strong evidence that fingerprint distortions are the main obstacle to breeding of mammals for nationality,” says co-author Joan-Zeng Lau of Sun Yat Sen University in Guangzhou.
“This approach can significantly improve the development results of fetal stem cells and cloned animals, which paves a promising path to the advancement of renewal medicine.”
Researchers note several restrictions that their work still needs to be treated. For one reason, only 11.8 % of viable embryos were able to develop until birth, and not all the puppies who lived in adulthood due to development defects.
Most of those who live to adulthood have changed growth and a short age. Also, the mice that lived to the stage of adulthood were sterile, although they showed an increase in the efficiency of cloning.
“More adjustments to the genes can be made to generate healthy dual mice capable of producing vibrant chains and lead to new treatment strategies for diseases associated with the process,” says CAS.
The team will continue to study how to adjust genes that may lead to embryos with higher potential. It also aims to extend the experimental methods developed in mice into large animals, including monkeys.
However, they notice that this will require a great time and effort because the fingerprint genes groups in the monkeys differ greatly from those in the mice.
Whether this technology will eventually apply to the solution of human diseases still unclear. Ethical guidelines of the International Association for Stem Cell Research for Stem Cell Research do not allow genetic liberation for reproductive purposes, nor the use of chant derived from human stem cells to reproduce because they are currently not safe.
On these news, genetic engineering and cloning research
author: Christopher seat
source: Cell Press
communication: Christopher seat – cell pressure
image: The image is attributed to news of neuroscience
The original search: Open access.
“Bettical birth offsWritten by Wei and others. The cell stem cell
a summary
Bettical birth offs
The fingerprint distortions constitute a great challenge in applications that involve fetal stem cells, stem cells with fair capabilities, and animal cloning, with no global correction method due to their complexity and random nature.
In this study, we targeted these defects in its source-Embryos of parents of the same sex-sleep to create a stable imprint that can be maintained once again In mammal cells.
Using dual -father mouse embryos, which show high -end fingerprint defects, are usually unlikely, we have provided tire mutations, genes deletion, organizational liberations at 20 main printed sites survival.
Results provide strong evidence that fingerprint distortions are a key obstacle with sexual reproduction in mammals.
Moreover, this approach can significantly improve the development results of fetal stem cells and cloned animals, which opens promising ways to progress in renewal medicine.
2025-01-28 20:42:00
